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Proficiency Testing
NASCOLA provides proficiency testing for North American laboratories to evaluate and improve their diagnostic testing for coagulation disorders. Participation in the proficiency testing program requires NASCOLA membership.

You are welcome to contact us for more detailed information about this testing.

Please read further for additional information regarding the NASCOLA Proficiency Testing Program.

2015 NASCOLA Fees and Module Programs 


Price in USD

Thrombophilia module *
Antithrombin (activity and antigen), Protein C (activity [chromogenic and clotting] and antigen), Protein S activity, Protein S antigen (total and free), APC Resistance



Lupus Anticoagulant / Antiphospholipid Antibodies module*
Anticardiolipin and anti-β 2 glycoprotein I antibodies


Coagulation Factor module I*

Factors VIII (clotting and chromogenic), IX, XI and XII


Coagulation Factor module II*

Factors II, V, VII and X


Von Willebrand Factor module* 
Antigen, activity, collagen binding, multimers, factor VIII


D-Dimer module*  


Factor VIII inhibitor module**


Thrombin Generation Test (TGT) module**


Heparin Induced Thrombocytopenia (HIT) module – Immunological assays***


Unfractionated Heparin Monitoring (anti-Xa)*


Low-molecular weight Heparin Monitoring (anti-Xa)*


Homocysteine module* 


Anticoagulant drug testing: Orgaran**


Anticoagulant drug testing: Fondaparinux**


Anticoagulant drug testing: Rivaroxiban**


Anticoagulant drug testing: Argatroban**


Anticoagulant drug testing: Dabigatran**


Factor XIII module* 


Fibrinolysis I module*
Plasminogen, Antiplasmin


Fibrinolysis II module*
T-PA (antigen), PAI-1 (antigen and activity)


 TEG/ROTEM (2015-1 and 3)  160
 TEG/ROTEM additional instruments (up to 4 additional may be ordered)  95 each

Platelet Dense Granule Deficiency (DGD) module
2 surveys per year


Postanalytical interpretation of platelet aggregation tests
2 surveys per year, 4-5 cases/survey


 Screen Module (APTT, PT/INR and Fibrinogen)                    
□  1 instrument     □  2 instruments    □  3 instruments    □  4 instruments    □  5 instruments
Case Studies on Bleeding Disorders  This survey will provide plasma and probably also DNA, and a case description. Based on the case description, participants can make decisions on which test should be performed to find the correct diagnosis. The idea is to follow the differential diagnostic strategy normally used in your own clinical laboratory. When DNA is provided we will ask also for the underlying genetic defect.

The focus in this survey is not primarily on the analytical quality but on finding the correct diagnosis, including the tests needed to perform to come to the right diagnosis.



*4 surveys per year: 2015-1, 2015-2, 2015-3, 2015-4

**2 surveys per year: 2015-2, 2015-4

***1 survey per year: 2015-3

Molecular Testing Modules:  (2 surveys per year)

(collaboration with DGKL and ECAT - participating laboratories will receive reports on the parameters that they evaluate from DGKL)
800 ng lyophilized DNA supplied – usually sufficient for all tests
1 set - $160; 2 sets - $220; 3 sets - $300; 4 sets - $400; 5 sets - $500; 6 sets – $575; 7 sets - $650



MG1 Set A:  FV-Leiden, Prothrombin, MTHFR (C677T, A1298C), PAI-I 4G5G





MG1 Set B:  FXIII V34L, GPIIIa, βFib (g455a), VKORC1 (G-1639A/C1173T), FXII c46t,  FV-H1299R





MG1 Set C:  a1 PI, Apo E, ApoB100, ACE, CETP





MG1 Set D:  Aldo B (149,174,334), HFE (H63D, C282Y, S65C), LCT c-13910t, NOD2  (R702W, G908R, L1007fins C)





MG1 Set E:  M. Wilson (ATP7B-C3207A), FSAP (Marburg-I), ITGA2 Gplalla C807T, Col1A1 SP1, VDR (BsmI/Apal,TaqI)





MG1 Set F:
Factor VII (R353Q), AT3 Cambridge Typ I/II, CYP3A5*3





MG2 Set A: TPMT, CYP2C8 (K399R), CYP2C9 *2/*3, UGT1A1 (*28), DPD Ex 14 skipping, BCHE A/K




  MG2 Set B: K-Ras: Codon 12/13/61, BRAF V600E  160  
  MG2 Set C: HLA-B27, TNF alpha (238, 308)  160  
  MG2 Set D: CYP2D6, CYP2C19 (*2/*17)  160  
  MG2 Set E: HLA B*5701, CYP2B6*6  160  


DNA Isolation and FV genotyping (2 surveys per year)




DNA Sequencing and Interpretation (2 surveys per year)

Participant sequences DNA sample. One sample is linked to a case report and interpretation is provided.



NASCOLA Membership Dues and ECAT Program Charges are paid once, regardless of the number of PT/EQA Modules ordered. A NASCOLA membership account must be created before placing an order.


NASCOLA Membership Dues


NASCOLA Membership Dues

Institutional Member (clinical labs)*……………………………… …$170 USD

Associate Member (vendors)*………………………………………$1400 USD

Individual Member………………………………………………………….$50 USD

           *eligible to order PT/EQA modules


Based on membership type, as outlined

Annual ECAT Subscription Fee (result submission via internet and data analyses) – single annual charge with orders of one or more proficiency testing modules

Internet result submission and internet access to reports
Internet result submission and internet access to reports plus printed copy sent by post




Additional Information:

NASCOLA is a nonprofit organization whose mission is to improve diagnostic coagulation testing, through proficiency testing, critical evaluation, guideline development, enhanced communication, collaboration, education and research.

Clinical Laboratories can join NASCOLA as an “Institutional Member”. Companies (that manufacture, distribute or provide other services in the field of Coagulation) can join NASCOLA as “Associate Members.” Individual memberships in NASCOLA are also available. Institutional and Associate Members have the option to participate in the proficiency testing/external quality assessment (PT/EQA) program that NASCOLA offers in collaboration with ECAT Foundation. Additional privileges, for all categories of NASCOLA membership, include NASCOLA website access to educational and resource materials (open for all interested specialized coagulation laboratory staff of an Institutional Member, and to all interested company representatives of Associate Members). Trainees (physician and MT) of NASCOLA institutional members are also eligible to join (membership complimentary).

NASCOLA holds 1 major scientific conference per year, and 1-2 general membership meetings, often in conjunction with NASCOLA scientific conferences and other national meetings (ISTH, THSNA, ISLH, Mayo Coagulation Testing Quality). For 2015, NASCOLA will hold a joint conference with the International Society of Laboratory Hematology at the Sheraton Chicago Hotel & Towers in Chicago, Illinois from May 19-21, 2015.(see NASCOLA website Bulletin Board for details).

 NASCOLA is pleased to offer Proficiency Testing Modules for nonregulated, specialized coagulation analytes at substantially lower costs than competitors. PT/EQA challenges are scheduled for March, May, August and November 2015. For optimal assessments of testing quality, PT/EQA challenges include normal and abnormal clinical samples (distributed as lyophilized sample sets from ECAT). Participants receive individualized, confidential reports. NASCOLA posts summary analyses (on the website) prior to these send-outs, to allow members expedited access to survey data. NASCOLA annual fees (by membership category) and 2015 Module Programs (available to Institutional and Associate Members only) are outlined in detail in the appended Table. Orders placed later than January 6, 2015 will be prorated (based on number of remaining surveys). 

If you would like to join NASCOLA, or would like more information on the benefits of membership, contact us at or send an e-mail to


To review a D-DIMER SAMPLE REPORT, SUMMARY REPORT and INTERPRETATION choose one of the following links:

D-Dimer Sample Report

Explanation of Long Term CV Report

Survey Summary Report